A 3′ UTR-derived non-coding RNA RibS increases expression of cfa and promotes biofilm formation of Salmonella enterica serovar Typhi.

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dc.contributor.author Zhao, X.
dc.contributor.author Liu, R.
dc.contributor.author Tang, H.
dc.contributor.author Osei-Adjei, G.
dc.contributor.author Xu, S.
dc.contributor.author Zhang, Y.
dc.contributor.author Huang, X.
dc.date.accessioned 2022-09-08T09:45:42Z
dc.date.available 2022-09-08T09:45:42Z
dc.date.issued 2018
dc.identifier.other 10.1016/j.resmic.2018.04.007
dc.identifier.uri https://pubmed.ncbi.nlm.nih.gov/29751065/
dc.identifier.uri http://atuspace.atu.edu.gh:8080/handle/123456789/212
dc.description.abstract Bacterial non-coding RNAs (ncRNAs) are widely studied and found to play important roles in regulating various cellular processes. Recently, many ncRNAs have been discovered to be transcribed or processed from 3' untranslated regions (3' UTRs). Here we reported a novel 3' UTR-derived ncRNA, RibS, which could influence biofilm formation of Salmonella enterica serovar Typhi (S. Typhi). RibS was confirmed to be a ∼700 nt processed product produced by RNase III-catalyzed cleavage from the 3' UTR of riboflavin synthase subunit alpha mRNA, RibE. Overexpression of RibS increased the expression of the cyclopropane fatty acid synthase gene, cfa, which was located at the antisense strand. Biofilm formation of S. Typhi was enhanced by overexpressing RibS both in the wild type strain and cfa deletion mutant. Deletion of cfa attenuated biofilm formation of S. Typhi, while complementation of cfa partly restored the phenotype. Moreover, overexpressing cfa enhanced the biofilm formation of S. Typhi. In summary, RibS has been identified as a novel ncRNA derived from the 3' UTR of RibE that promotes biofilm formation of S. Typhi, and it appears to do so, at least in part, by increasing the expression of cfa. en_US
dc.language.iso en en_US
dc.relation.ispartofseries vol;169
dc.subject Biofilm en_US
dc.subject Non-coding RNA en_US
dc.subject RibS en_US
dc.subject Salmonella enterica serovar Typhi en_US
dc.subject Cfa en_US
dc.title A 3′ UTR-derived non-coding RNA RibS increases expression of cfa and promotes biofilm formation of Salmonella enterica serovar Typhi. en_US
dc.type Article en_US


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