Serum potassium, sodium, and chloride levels in sickle cell disease patients and healthy controls: a case-control study at Korle-Bu teaching hospital, Accra.

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dc.contributor.author Antwi-Boasiako, C.
dc.contributor.author Kusi-Mensah, Y. A.
dc.contributor.author Hayfron-Benjamin, C.
dc.contributor.author Aryee, R.
dc.contributor.author Dankwah, G. B.
dc.contributor.author Abla, K. L.
dc.contributor.author Botchway, F.
dc.contributor.author Sampene-Donkor, E
dc.date.accessioned 2022-09-05T08:42:44Z
dc.date.available 2022-09-05T08:42:44Z
dc.date.issued 2019
dc.identifier.other 10.1177/1177271919873889.
dc.identifier.uri https://pubmed.ncbi.nlm.nih.gov/31523130/
dc.identifier.uri http://atuspace.atu.edu.gh:8080/handle/123456789/200
dc.description.abstract The activity of Na+-K+ ATPase is altered in sickle cell disease (SCD), which affects serum electrolyte levels. This alteration is associated with several complications in sickle cell patients. This study evaluated the serum levels of sodium, potassium, and chloride in patients with SCD. The study was a case-control cross-sectional study involving 120 SCD patients in the steady state and 48 'healthy' controls. The SCD patients were made up of 69 HbSS patients and 41 HbSC patients. Serum electrolyte levels (Na+, K+, and Cl-) were measured using a Flame Atomic Absorption Spectrometer (Variant 240FS; Varian Australia Pty Ltd). Serum sodium levels were significantly lower in the sickle cell patients, compared with their 'healthy' counterparts (P = .0001). Although the study found significantly higher serum levels of potassium in the SCD patients (P = .0001), there was no significant difference in serum chloride levels between patients with SCD and the controls (P = .098). Serum sodium and chloride levels were not significantly different in both HbSS and HbSC patients (P = .197 and P = .553, respectively). The level of serum potassium in the HbSS patients was, however, significantly higher compared with those with the HbSC genotype (P = .0001). There is higher efflux of K+ from the intracellular into the extracellular space in HbSS patients, which may lead to red cell membrane dysfunction and associated complications. en_US
dc.language.iso en en_US
dc.publisher Sage en_US
dc.relation.ispartofseries vol;14
dc.subject Sodium en_US
dc.subject Chloride en_US
dc.subject Potassium en_US
dc.subject Sickle cell disease en_US
dc.title Serum potassium, sodium, and chloride levels in sickle cell disease patients and healthy controls: a case-control study at Korle-Bu teaching hospital, Accra. en_US
dc.type Article en_US


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