CalR is required for the expression of T6SS2 and the adhesion of Vibrio parahaemolyticus to HeLa cells

Zhang, L.; Osei-Adjei, G.; Zhang, Y.; Gao, H.; Yang, W.; Zhou, D.; Zhang, Y.

dc.contributor.author	Zhang, L.
dc.contributor.author	Osei-Adjei, G.
dc.contributor.author	Zhang, Y.
dc.contributor.author	Gao, H.
dc.contributor.author	Yang, W.
dc.contributor.author	Zhou, D.
dc.contributor.author	Zhang, Y.
dc.date.accessioned	2022-09-08T10:51:19Z
dc.date.available	2022-09-08T10:51:19Z
dc.date.issued	2017
dc.identifier.other	10.1007/s00203-017-1361-6
dc.identifier.uri	https://link.springer.com/article/10.1007/s00203-017-1361-6
dc.identifier.uri	http://atuspace.atu.edu.gh:8080/handle/123456789/222
dc.description.abstract	Vibrio parahaemolyticus expresses one major virulence determinant T6SS2, which is constituted into three putative operons, i.e., VPA1027-1024, VPA1043-1028, and VPA1044-1046. CalR, a LysR-type transcriptional regulator, was originally identified as a repressor of the swarming motility and T3SS1 gene expression. As shown in this study, CalR binds to the promoter-proximal region of each of the three operons to activate their transcription, and moreover, CalR activates the adhesion of V. parahaemolyticus to HeLa cells. In addition, competitive EMSAs demonstrated that CalR acts as an antagonist of H–NS in V. parahaemolyticus. Collectively, these studies confirmed a new physiological role for CalR in V. parahaemolyticus.	en_US
dc.language.iso	en	en_US
dc.publisher	Springer Link	en_US
dc.relation.ispartofseries	vol;199
dc.subject	Vibrio parahaemolyticus ·	en_US
dc.subject	T6SS2	en_US
dc.subject	CalR	en_US
dc.title	CalR is required for the expression of T6SS2 and the adhesion of Vibrio parahaemolyticus to HeLa cells	en_US
dc.type	Article	en_US